13 December 2012

Cancer Stem Cells From Kidney Tumors Promises New Therapy In Treating The Disease

Cancer stem cells isolated from kidney tumors may give rise to new and effective treatments in treating aggressive forms of the disease.

Stem cell technology has been gaining wide attention because of its potential to treat diseases and conditions that with conventional methods are difficult even impossible. This technology is centered on embryonic and pluripotent stem cells. These are cells that have the capability to differentiate (transform) into various other cells and even organs.

But aside from these type of stem cells, there are other kinds of stem cells around.

There are blood stem cells (hematopoietic stem cells) that resupplies blood cells. There are also heart stem cells recently discovered that are responsible for heart tissues. Even the skin has stem cells.

These stem cells are limited to the organ it is associated with. There are procedures that can transform them back to its pluripotent stage but that technology is still in its early stages.

Cancer Stem Cells

There are also cancer stem cells (CSC). These behave the same way as stem cells do but instead of building back healthy tissues, these are responsible for creating cancer tumors. They are tumor forming stem cells (tumorigenic).

CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. They are present in tumors and may cause a relapse in the disease and even be responsible for metastisis (growth and propagation of cancer tumors in other parts of the body).

Cancer stem cells isolated from kidney tumors

Scientists have isolated cancer stem cells that lead to the growth of Wilms' tumours, a type of cancer typically found in the kidneys of young children. The researchers have used these cancer stem cells to test a new therapeutic approach that one day might be used to treat some of the more aggressive types of this disease. The results are published online in EMBO Molecular Medicine.

"In earlier studies, cancer stem cells were isolated from adult cancers of the breast, pancreas and brain but so far much less is known about stem cells in paediatric cancers," remarked Professor Benjamin Dekel, head of the Pediatric Stem Cell Research Institute and a senior physician at the Sheba Medical Center and the Sackler School of Medicine at Tel Aviv University, Israel. "Cancer stem cells contain the complete genetic machinery necessary to start, sustain and propagate tumour growth and they are often referred to as cancer-initiating cells. As such, they not only represent a useful system to study cancer development but they also serve as a way to study new drug targets and potential treatments designed to stop the growth and spread of different types of cancer." He added: "We have demonstrated for the first time the presence of cancer stem cells in a type of tumour that is often found in the kidneys of young children."

Video: Targeting Cancer Stem Cells

Wilms' tumours are the most prevalent type of tumour found in the kidneys of children. While many patients respond well if the tumours are removed early by surgery and if patients are given chemotherapy, recurrences may occur and the cancer can spread to other tissues increasing the risks to the health of the patient. Conventional chemotherapy is toxic to all cells in the body and if given to children may lead to the development of secondary cancers when they become adults. Scientists are looking for ways to ensure that drugs are targeted specifically to tumour cells and some cells in a tumour may be more important to eradicate than others.

The researchers were able to remove parts of the tumours of cancer patients and graft them into mice. This procedure led to the growth of human tumours in mice. Cancer stem cells were identified in these tumours and it was shown that only the cancer stem cells and not the other cancer cells led to the development of new tumours upon grafting into additional mice. This process could be repeated multiple times and the animals could be used to study the development of cancer and test the action of potential new cancer drugs against Wilms' tumours.

"We identified several biomarkers, including molecules that are on the cell surface, cell signaling molecules and microRNAs, that make it possible to distinguish between cancer stem cells or cancer-initiating cells and the rest of the cells in the tumour that are less likely to lead to cancer. In further experiments, we were able to show that an antibody drug that targets one such biomarker, the neural cell adhesion molecule, was able to either almost completely or in some cases completely eradicate the tumours that we induced in mice," added Dekel. "This preliminary result suggests that the cancer stem cells that we have identified, isolated and propagated may serve as a useful tool to look for new drug targets as well as new drugs for the treatment of Wilms' tumours."

Further work is needed to identify more precisely how the antibody drug used in the study (lorvotuzumabmertansine) affects cancer stem cell populations and to test the long-term suitability of the antibody drug to treat Wilms' tumours in humans.


European Molecular Biology Organization
EMBO Molecular Medicine
Pediatric Stem Cell Research Institute
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