09 January 2013

Virulent Form of Helicobacter pylori (H. pylori) Bacteria May Protect Against Stroke and Cancer

Researchers suggest that an especially virulent strain of the gut bacterium Helicobacter pylori (H. pylori)may protect stroke and some types of cancer.

A stroke is a disease where blockages (called clots) in the artery obstruct the flow of blood to the brain. Without the blood that carries oxygen and nutrients to it, brain cells start to die and may cause permanent damage.

Stroke is the fourth leading cause of death in the United States. The most popular type of stroke are Ischemic strokes. 87% of all strokes are of this type.

The American Heart Association defines it as an obstruction within a blood vessel supplying blood to the brain. This is due to the development of fatty deposits lining the vessel walls. This condition is called atherosclerosis.

Depending on what part of the brain is affected, cognitive and physical activities deteriorate. If the stroke affects the right side of the brain the following may occur:
  • Paralysis on the left side of the body
  • Vision problems
  • Quick, inquisitive behavioral style
  • Memory loss
If the left brain is affected, the person may experience the following:
  • Paralysis on the right side of the body
  • Speech/language problems
  • Slow, cautious behavioral style
  • Memory loss
There are some cases where the stroke targets the brain stem. This would result in having both sides of the brain are affected. Patients who experience this would experience total paralysis from the neck down and would be unable to speak.

Treatment for stroke victims should be immediate. The patient must be in the hospital where anti-clot medication is administered within 3 hours of experiencing symptoms.

Long term treatment requires physical, cognitive, and psychological therapy as well as medication to avoid future strokes.

Using Bacteria For Stroke Treatment

A new study by NYU School of Medicine researchers reveals that an especially virulent strain of the gut bacterium Helicobacter pylori (H. pylori) isn't implicated in the overall death rate of the U.S. population, and may even protect against stroke and some cancers. The findings, based a nationwide health survey of nearly 10,000 individuals over a period of some 12 years, are published online, January 9, in the journal Gut.

Those individuals carrying the most virulent strain of H. pylori, the study found, had a 55 percent reduced risk of deaths from stroke compared with their counterparts who were not infected with H. pylori. Participants with the most virulent strain also had a 45 percent reduced risk of death from lung cancer.

These surprising findings emerged from an analysis by Yu Chen, PhD, MPH, associate professor of population health and environmental medicine, and Martin J. Blaser, MD, professor of internal medicine and professor of microbiology, of individuals who participated in a national survey designed to assess the health and nutritional status of adults and children in the United States. Previous studies by Dr. Blaser have confirmed the bacterium's link to gastric diseases ranging from gastritis to stomach cancer. He and Dr. Chen have more recently shown that H. pylori may protect against childhood asthma. The most virulent H. pylori strains have a gene called cagA.

"The significance of this study is that this is a prospective cohort of participants representative of the U.S. population with a long follow-up," says Dr. Chen. "We studied both the overall H. pylori as well as cagA strain of H. pylori, which is more interactive with the human body. We found that H. pylori is not related to the risk of death from all causes, despite it being related to increased risk of death from gastric cancer."

"This finding confirms earlier work, however, that gastric cancers are now uncommon in the United States," says Dr. Chen. "We also found that H. pylori was related to a reduced risk of stroke and lung cancer, and these effects were stronger for the cagA strain, suggesting its mixed role in human health," she says.

Video: How it feels to have a stroke

H. pylori, an ancient bacterium, lives in the mucous layer lining the stomach where, until recently, it survived for decades. More than half of the world's population harbor H. pylori in their upper gastrointestinal tract. Mainly transmitted in families, the bacterium is usually acquired before age 10. In developing countries H. pylori is still prevalent, but is vanishing in the developed world thanks to better sanitation and widespread use of antibiotics.

To better understand the relationship between H. pylori and the overall death rate, or all-cause mortality, the researchers analyzed data from 9,895 participants in the National Health and Nutrition Surveys (NHANES III), enrolled from 1988 to 1994. Test results for H. pylori and cagA were available on 7,384 subjects at the time of enrollment, and participants were followed until 2000.

There was no association of either H. pylori-positivity or cagA-positivity with all-cause mortality in the population, the researchers found. Participants with and without H. pylori experienced a similar risk of death from all causes. Consistent with past reports, a strong association was observed between H. pylori and gastric cancer mortality, according to the study. Individuals who were H. pylori positive were 40 times more likely to die from gastric cancer. The study also found that participants with cagA-positivity had a 55 percent reduced risk of deaths from stroke compared with their counterparts who were H. pylori negative/ cagA-negative. Participants with cagA-positivity also had a 45 percent reduced risk of deaths from lung cancer.

"The most interesting finding was that there is a strong inverse association with stroke which could be protective," says Dr. Blaser. "There is some precedent for this and it is possible that the same cells (T reg cells) that H. pylori induces that protect against childhood asthma could be the protective agents, however, the findings need to be confirmed."


NYU Langone Medical Center / New York University School of Medicine
American Stroke Association
American Heart Association
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