Showing posts with label KS. Show all posts
Showing posts with label KS. Show all posts

02 October 2012

Treating Kaposi's Sarcoma Through Blocking of Sugar Binding Protein Galectin-1


Kaposi's sarcoma is a cancerous tumor caused by the human herpesvirus 8 (HHV8). KS as it is usually called is also known as Kaposi's sarcoma-associated herpesvirus (KSHV).

Kaposi's Sarcoma is named after Hungarian dermatologist Moritz Kaposi who discovered the disease in 1872.

The tumors appear bluish-red or as purple bumps on the skin. They first appear in the feet or ankles, thighs, arms, hands, and face. Kaposi's Sarcoma tumors can also manifest in other parts of the body as well. Sometimes, the tumors appear inside the body such as in the lungs, gastrointestinal tract, and other organs.

In the 1980's when AIDS first appeared, Kaposi's sarcoma was often associated with it. AIDS related KS is caused by the interaction between the Human immunodeficiency virus (HIV), a weakened immune system, and HHV-8. Treatment of KS in AIDS patients does not affect the chance of survival from AIDS.

Unlike other cancers, the cause of Kaposi's Sarcoma has been positively identified. The virus, HHV-8, is transmitted by the exchange of saliva between an infected person and an uninfected one. It can also be acquired through organ transplantation and to a lesser extent, blood transfusion.

There is no cure for KS but the disease can be slowed down. Antiviral therapy, chemotherapy, crytherapy (freezing), and radiation therapy are some of the treatments used to managed KS but this does not guarantee that an outbreak of lesions will not happen.

Sugar-free approach to treating Kaposi sarcoma

A sugar-loving protein drives the growth of Kaposi sarcoma (KS) tumors, according to a study published on October 1st in The Journal of Experimental Medicine. Interfering with these sugary interactions inhibited growth of Kaposi sarcomas in mice, hinting at the potential for new treatment strategies in humans.