Osteoporosis is a disease of the bones where the bone tissue thins and bone density decreases over time. This leads to an increased risk of bone fracture. The World Health Organization (WHO) defines Osteoporosis as a bone mineral density that is 2.5 standard deviations or more below the mean peak bone mass (average of young, healthy adults) as measured by DXA; the term "established osteoporosis" includes the presence of a fragility fracture.
Osteoporosis is the most common type of bone disease.
It is estimated that about 1 out of 5 American women over the age of 50 have osteoporosis. Around 50% of all women over the age of 50 will have a fracture of the hip, wrist, or vertebra (bones of the spine).
Osteoporosis occurs when the body fails to form enough new bone, when too much old bone is reabsorbed by the body, or both.
Some causes for osteoporosis are:
- Long periods of bed confinement
- Chronic rheumatoid arthritis, chronic kidney disease, eating disorders
- Taking corticosteroid medications (prednisone, methylprednisolone) every day for more than 3 months, or taking some antiseizure drugs
- Hyperparathyroidism
- Vitamin D deficiency
Some medications that are used to treat osteoporosis are:
- Bisphosphonates - primary drugs used to both prevent and treat osteoporosis in postmenopausal women.
- Calcitonin - slows the rate of bone loss and relieves bone pain.
- Parathyroid Hormone - Teriparatide (Forteo) is approved for the treatment of postmenopausal women who have severe osteoporosis and are considered at high risk for fractures.
- Raloxifene (Evista) - used for the prevention and treatment of osteoporosis. Raloxifene is similar to the breast cancer drug tamoxifen
Increased Risk of Eye Disease
Drugs that are commonly used to prevent osteoporosis may increase the risk of serious inflammatory eye disease in first-time users, found an article in CMAJ (Canadian Medical Association Journal).
Oral bisphosphonates, the most commonly prescribed class of drugs used to prevent osteoporosis, have been linked to adverse events such as unusual fractures, irregular heartbeat, and esophageal and colon cancer. Some case reports have shown an association between these drugs and anterior uveitis and scleritis, inflammatory eye diseases that can seriously affect vision.
