04 April 2012

Coffee and Exercise May Help Protect Against Skin Cancer

Caffeine is a stimulant that is found in seeds, leaves, and fruits of some plants. The majority of caffeine is derived from coffee beans. It is a bitter, white crystalline xanthine alkaloid. As a central nervous system stimulant, caffeine is the most consumed psychoactive drug.

90% of people in the world use caffeine in one form or another. 80% of US adults consume an average of 200mg of caffeine every day. The US FDA treats caffeine both as a drug and a food additive. It is legal and unregulated in nearly all parts of the world

Caffeine and exercise may be protective against skin cancer caused by sun exposure

There has been studies linking caffeine's beneficiary effects against skin cancer. In a study, Oral caffeine during voluntary exercise markedly inhibits skin carcinogenesis and decreases cytokines associated with inflammation in UVB-treated mice, Yaoping Lou presents their findings.

The abstract states, "In previous studies, we found that treatment of female SKH-1 mice with either oral administration of caffeine or voluntary running wheel exercise (RW) inhibited the formation of UVB-induced skin tumors. In the present study, we determined whether RW in combination with oral caffeine has a synergistic inhibitory effect on UVB-induced skin carcinogenesis..."

The combined effects of exercise plus caffeine consumption may be able to ward off skin cancer and also prevent inflammation related to other obesity-linked cancers.

"We found that this combination treatment can decrease sunlight-caused skin cancer formation in a mouse model," said Yao-Ping Lu, Ph.D., associate research professor of chemical biology and director of skin cancer prevention at the Rutgers Ernest Mario School of Pharmacy in Piscataway, N.J. He presented these findings at the AACR Annual Meeting 2012.

"I believe we may extrapolate these findings to humans and anticipate that we would benefit from these combination treatments as well," Lu added.

Video: Caffeine and Skin Cancer

The researchers evaluated the effects of caffeine and exercise on mice at high risk for developing skin cancer. Results showed that mice that took a dose of caffeine and exercised with a running wheel experienced 62 percent fewer skin tumors. The volume of tumors also decreased by 85 percent compared with the mice that did not consume caffeine or exercise.

Positive effects were found with either caffeine or exercise alone, but to a lesser extent. Researchers observed a 27 percent reduction in tumors in caffeine-only mice and a 61 percent reduction in tumor size. In the exercise-only mice, researchers found that tumor activity decreased by 35 percent and tumor volume decreased by 70 percent.

The researchers also found that exercise and caffeine reduced weight and inflammation. They fed mice a high-fat diet of omega-6 fatty acid-rich foods and measured the volume of the parametrial fat pad (the largest fat pad in a mouse) after two weeks of exercise and/or caffeine treatment.

Mice that had caffeine and exercised had a fat pad weight decrease of 63 percent. Caffeine-only mice had a 30 percent decrease, and exercise-only mice had a 56 percent decrease. Development and size of cancer decreased as well. The link, Lu believes, is inflammation, which dropped as much as 92 percent in mice that exercised and consumed caffeine.


American Association for Cancer Research
Rutgers Ernest Mario School of Pharmacy
National Institutes of Health
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