27 September 2012

Research Show Relationship Between Intestinal Bacteria and Type 2 Diabetes

The human body is a host to thousands of species of bacteria. The bulk of these bacteria live in the human intestinal tract or the gut. These bacteria perform activities that are beneficial to the body.

Bacteria that are not harmful and are beneficial to the body are said to be part of the normal flora. Since "flora" pertains to plants, the term "biota" is also used although generally, flora is an accepted word to describe this microsystem.

Human gut flora, consists of an average of 500 different species. They serve various beneficial functions such as fermenting unused energy substrates, training the immune system, preventing growth of harmful, pathogenic bacteria, regulating the development of the gut, producing vitamins (such as biotin and vitamin K) for the host, and producing hormones to direct the host to store fats.

Although the relationship of gut flora and the human body is generally beneficial and mutual, there are certain situations and conditions that bacteria can cause infections, disease, and even cancer.

Gut bacteria could cause diabetes

The number of people suffering from type 2 diabetes world-wide has risen rapidly in recent years, and scientists estimate that just as many people could be suffering from the illness without realising it. New research now indicates that your gut bacteria can reveal whether you suffer from the disease.

"We have demonstrated that people with type 2 diabetes have a high level of pathogens in their intestines," says professor Jun Wang from the University of Copenhagen's Department of Biology and Novo Nordisk Foundation Center for Basic Metabolic Research.

Video: Relationship of Intestinal Bacteria and Type 2 Diabetes

Important intestinal bacteria

The 1.5 kilograms of bacteria that we each carry in our intestines have an enormous impact on our health and well being. The bacteria normally live in a sensitive equilibrium but if this equilibrium is disrupted our health could suffer. In the new study, scientists examined the intestinal bacteria of 345 people from China, of which 171 had type 2 diabetes. The team managed to identify clear biological indicators that someday could be used in methods that provide faster and earlier diagnosis of type 2 diabetes.

The research, which was recently published in the scientific journal Nature, also demonstrated that people with type 2 diabetes have a more hostile bacterial environment in their intestines, which can increase resistance to different medicines.

Similar studies carried out on sufferers of type 2 diabetes in Denmark also discovered a significant imbalance in the function of their intestinal bacteria and composition. Future Danish studies will examine whether intestinal bacteria is already abnormal in people that are deemed to be at risk of developing diabetes.

"We are going to transplant gut bacteria from people that suffer from type 2 diabetes into mice and examine whether the mice then develop diabetes," says another of the lead scientists behind the project, professor Oluf Borbye Pedersen from the University of Copenhagen and centre director at LuCamp, the Lundbeck Foundation Centre for Applied Medical Genomics in Personalised Disease Prediction, Prevention and Care.

International research team investigates gut bacteria

By working together, a team scientists from the University of Copenhagen and the Beijing Genomics Institute (BGI) was able to make to several breakthroughs in the field of 'metagenomics'.

Scientists working on the EU research project MetaHIT have uncovered more than 3.3 million genes from gut bacteria found in people from Spain and Denmark. These genes could play a key role in understanding and treating a range of serious illnesses. According to Professor Karsten Kristiansen from the University of Copenhagen's Department of Biology, the recent discovery is an important step in the comprehensive international research that is currently underway to investigate the interplay between intestinal bacteria and health.

"The European and Chinese working on the MetaHIT project were able to make important new discoveries about the relationship between intestinal bacteria and health. The new discovery indicates a possible connection between type 2 diabetes and the intestinal bacteria in Chinese people," Kristiansen says.

"It is important to point out that our discovery demonstrates a correlation. The big question now is whether the changes in gut bacteria can affect the development of type 2 diabetes or whether the changes simply reflect that the person is suffering from type 2 diabetes."


University of Copenhagen
Novo Nordisk Foundation Center for Basic Metabolic Research
Beijing Genomics Institute (BGI)
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