Researchers at Cold Spring Harbor Laboratory (CSHL) dicovered a new pathway that controls fear memories and behavior in the mouse brain, offering mechanistic insight into how anxiety disorders may arise.
It is known that the amygdala is responsible for processing memory, decision-making, and emotional reactions. This covers fear memories and fear learning. This latest discovery which is published in Nature, extends the understanding further by finding out what are the controlling factors in and of the amygdala.
The researchers note that the processing of fear is stored within a distinct region of the brain. They found neuron circuit (called the PVT and CeL; see image) that controls fear. Disrupting the circuit results in a huge reduction of fear and strengthening it does the opposite. They also note that the chemical messenger used to transmit and control the fear emotion is BDNF, a molecule already associated with anxiety disorders.
The discovery of the neural circuit can be the basis for new therapies for treatment of anxiety disorders.
It is known that the amygdala is responsible for processing memory, decision-making, and emotional reactions. This covers fear memories and fear learning. This latest discovery which is published in Nature, extends the understanding further by finding out what are the controlling factors in and of the amygdala.
The researchers note that the processing of fear is stored within a distinct region of the brain. They found neuron circuit (called the PVT and CeL; see image) that controls fear. Disrupting the circuit results in a huge reduction of fear and strengthening it does the opposite. They also note that the chemical messenger used to transmit and control the fear emotion is BDNF, a molecule already associated with anxiety disorders.
The discovery of the neural circuit can be the basis for new therapies for treatment of anxiety disorders.